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Methamphetamine increases the release of very high levels of the brain chemical dopamine which is involved in motivation of the experience of pleasure and motor function which is a common mechanism of action for most drugs of abuse.Chronic methamphetamine abuse significantly changes how the brain functions.Noninvasive human brain imaging studies have shown alterations in the activity of the dopamine system that are associated with reduced motor performance and impaired verbal learning.Recent studies in chronic methamphetamine abusers have also revealed severe structural and functional changes in areas of the brain associated with emotion and memory which may your account for many of the emotional and cognitive problems observed in chronic methamphetamine abusers.In long term methamphetamine abuse can also lead to addiction a chronic and relapsing disease.These are characterized by compulsive drug seeking and use or accompanied by chemical and molecular changes in the brain.Some of these changes persist long after methamphetamine abuse is stopped and some reverse after sustained periods of abstinence (2-6 years).So its dont take best in man or woman of life.Stay away form drugs.(Its my personal advice)